Helen Robson attended the University of Oklahoma where she was a member of the Beta Theta chapter of Kappa Kappa Gamma, graduating with a degree in business. She married Samuel Moore Walton, founder of Wal-Mart Stores, Inc., on February 14, 1943.
An outstanding volunteer in a board spectrum of community programs, Walton received the KKG Alumnae Achievement Award in 1990, the Fraternity's highest honor for personal and professional achievement. Walton served as the first female Moderator of the Presbytery of Arkansas and the first female officer of the National Foundation Board of Trustees of the Presbyterian Church (USA). Walton also served on the Arkansas Governor's Child Care Task Force and the Governor's Commission on Literacy. In 1985, she and her husband established the Central American Scholars program, which she was actively involved with for years.
Following the death of her husband in 1992, ownership in Wal-Mart was left to Helen Walton and their four children. At one point in her life, Walton was the richest American and the eleventh-richest woman in the world. At the time of her death in 2007, she had an estimated net worth of $16.4 billion.